High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy With Cardiovascular Deep Learning.

Journal: JAMA cardiology
Published Date:

Abstract

IMPORTANCE: Early detection and characterization of increased left ventricular (LV) wall thickness can markedly impact patient care but is limited by under-recognition of hypertrophy, measurement error and variability, and difficulty differentiating causes of increased wall thickness, such as hypertrophy, cardiomyopathy, and cardiac amyloidosis.

Authors

  • Grant Duffy
    Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd A3600, Los Angeles, CA 90048, United States.
  • Paul P Cheng
    Department of Medicine, Division of Cardiology, Stanford University, Stanford, California.
  • Neal Yuan
    Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Bryan He
    Department of Computer Science, Stanford University, Stanford, California.
  • Alan C Kwan
    Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
  • Matthew J Shun-Shin
    Department of Cardiology, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Kevin M Alexander
    Department of Medicine, Division of Cardiology, Stanford University, Stanford, California.
  • Joseph Ebinger
    Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
  • Matthew P Lungren
  • Florian Rader
    Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • David H Liang
    Department of Medicine, Stanford University, Stanford, CA, USA.
  • Ingela Schnittger
    Department of Medicine, Stanford University, Palo Alto, CA, 94025.
  • Euan A Ashley
    Department of Genetics, Stanford University, Stanford, California, United States of America.
  • James Y Zou
    Department of Computer Science, Stanford University, Stanford, CA, USA. jamesz@stanford.edu.
  • Jignesh Patel
    Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Ronald Witteles
    Department of Medicine, Division of Cardiology, Stanford University, Stanford, California.
  • Susan Cheng
    Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
  • David Ouyang
    Division of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.