Comparative analysis of machine learning algorithms for multi-syndrome classification of neurodegenerative syndromes.

Journal: Alzheimer's research & therapy
Published Date:

Abstract

IMPORTANCE: The entry of artificial intelligence into medicine is pending. Several methods have been used for the predictions of structured neuroimaging data, yet nobody compared them in this context.

Authors

  • Leonie Lampe
    AICURA Medical GmbH, Berlin, Germany. leonie.lampe@aicura-medical.com.
  • Sebastian Niehaus
    Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, School of Medicine, TU Dresden, Dresden, Germany.
  • Hans-Jürgen Huppertz
    Swiss Epilepsy Centre, Klinik Lengg, Zurich, Switzerland.
  • Alberto Merola
    AICURA Medical GmbH, Berlin, Germany.
  • Janis Reinelt
    AICURA Medical GmbH, Berlin, Germany.
  • Karsten Mueller
    Max Planck Institute for Human Cognitive and Brain Sciences & Clinic for Cognitive Neurology, University Hospital Leipzig, Germany.
  • Sarah Anderl-Straub
    Department of Neurology, University of Ulm, Germany.
  • Klaus Fassbender
    Clinic and Polyclinic for Neurology, Saarland University Homburg, Germany.
  • Klaus Fliessbach
    Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, Germany.
  • Holger Jahn
    Clinic for Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
  • Johannes Kornhuber
    Clinic for Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nuremberg, Germany.
  • Martin Lauer
    Clinic for Psychiatry, Psychosomatic medicine and Psychotherapy, University Würzburg, Germany.
  • Johannes Prudlo
    Department of Neurology, DZNE, University of Rostock, Rostock, Germany.
  • Anja Schneider
    Clinic for Psychiatry and Psychotherapy, University of Goettingen, Germany.
  • Matthis Synofzik
    Department of Neurodegenerative Diseases, Centre for Neurology & Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Adrian Danek
    Clinic of Neurology, Ludwig Maximilian University of Munich, Germany.
  • Janine Diehl-Schmid
    Clinic and Polyclinic for Psychiatry & Psychotherapy, Technical University Munich, Germany.
  • Markus Otto
    Department of Neurology, University of Ulm, Germany.
  • Arno Villringer
    Clinic for Cognitive Neurology, University Clinic Leipzig, Leipzig, Germany.
  • Karl Egger
    Department of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany.
  • Elke Hattingen
    Department of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt, Germany.
  • Rüdiger Hilker-Roggendorf
    Department of Neurology, Klinikum Vest, Recklinghausen, Germany.
  • Alfons Schnitzler
    Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Martin Südmeyer
    Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Wolfgang Oertel
    Department of Neurology, Philips-University Marburg, Marburg, Germany.
  • Jan Kassubek
    Department of Neurology, University of Ulm, Ulm, Germany. jan.kassubek@uni-ulm.de.
  • Günter Höglinger
    Department of Neurology, Technical University of Munich, Munich, Germany.
  • Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences & Clinic for Cognitive Neurology, University of Leipzig, and German Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany.