Oxygen delivery in pediatric cardiac surgery and its association with acute kidney injury using machine learning.

Journal: The Journal of thoracic and cardiovascular surgery
PMID: 35840430

Abstract

OBJECTIVE: Acute kidney injury (AKI) after pediatric cardiac surgery with cardiopulmonary bypass (CPB) is a frequently reported complication. In this study we aimed to determine the oxygen delivery indexed to body surface area (Doi) threshold associated with postoperative AKI in pediatric patients during CPB, and whether it remains clinically important in the context of other known independent risk factors.

Authors

  • Alice Hayward
    Department of Perfusion, Great Ormond Street Hospital, London, United Kingdom.
  • Alex Robertson
    Department of Perfusion, Great Ormond Street Hospital, London, United Kingdom.
  • Timothy Thiruchelvam
    Department of Intensive Care, Great Ormond Street Hospital, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
  • Michael Broadhead
    Department of Anesthetics, Great Ormond Street Hospital, London, United Kingdom.
  • Victor T Tsang
    Institute of Cardiovascular Science, University College London, London, United Kingdom; Department of Cardiothoracic Surgery, Great Ormond Street Hospital, London, United Kingdom.
  • Neil J Sebire
    Health Data Research UK, London, UK.
  • Richard W Issitt
    Department of Perfusion, Great Ormond Street Hospital, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom; Digital Research, Informatics and Virtual Environment, NIHR Great Ormond Street Hospital BRC, London, United Kingdom. Electronic address: richard.issitt@gosh.nhs.uk.

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