Development and external validation of predictive algorithms for six-week mortality in spinal metastasis using 4,304 patients from five institutions.

Journal: The spine journal : official journal of the North American Spine Society
Published Date: Dec 1, 2022

Abstract

BACKGROUND CONTEXT: Historically, spine surgeons used expected postoperative survival of 3-months to help select candidates for operative intervention in spinal metastasis. However, this cutoff has been challenged by the development of minimally invasive techniques, novel biologics, and advanced radiotherapy. Recent studies have suggested that a life expectancy of 6 weeks may be enough to achieve significant improvements in postoperative health-related quality of life.

Authors

  • Aditya V Karhade
    Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Brian Fenn
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA, USA; Tufts University School of Medicine, Boston, MA, USA.
  • Olivier Q Groot
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
  • Akash A Shah
    David Geffen School of Medicine UCLA, Los Angeles, CA, USA.
  • Hung-Kuan Yen
    School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Mark H Bilsky
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Ming-Hsiao Hu
    Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan. Electronic address: minghsiaohu@yahoo.com.tw.
  • Ilya Laufer
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Don Y Park
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Daniel M Sciubba
    Department of Neurosurgery, The Johns Hopkins Hospital, 600 North Wolfe Street; Meyer Building, Room 7-109, Baltimore, MD 21287, USA. Electronic address: Dsciubb1@jhmi.edu.
  • Ewout W Steyerberg
    Department of Biomedical Data Sciences, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333 ZA The Netherlands.
  • Daniel G Tobert
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
  • Christopher M Bono
    1Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Mitchel B Harris
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA, USA.
  • Joseph H Schwab
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: jhschwab@mgh.harvard.edu.

Keywords

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