How physical techniques improve the transdermal permeation of therapeutics: A review.

Journal: Medicine
PMID: 35777055

Abstract

BACKGROUND: Transdermal delivery is very important in pharmaceutics. However, the barrier function of the stratum corneum hinders drugs absorption. How to improve transdermal delivery efficiency is a hot topic. The key advantages of physical technologies are their wide application for the delivery of previously nonappropriate transdermal drugs, such as proteins, peptides, and hydrophilic drugs. Based on the improved permeation of drugs delivered via multiple physical techniques, many more diseases may be treated, and transdermal vaccinations become possible. However, their wider application depends on the related convenient and portable devices. Combined products comprising medicine and devices represent future commercial directions of artificial intelligence and 3D printing.

Authors

  • Yan Gao
    Department of Rehabilitation Medicine, The First Affiliated Hospital of Shenzhen University, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
  • Lina Du
    Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Qian Li
    Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • Qi Li
    The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
  • Lin Zhu
    Institute of Environmental Technology, College of Environmental and Resource Sciences; Zhejiang University, Hangzhou 310058, China.
  • Meiyan Yang
    State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
  • Xiu Wang
    Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Bonian Zhao
    Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Shan Ma
    Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan, China.

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