Will microfluidics enable functionally integrated biohybrid robots?

Journal: Proceedings of the National Academy of Sciences of the United States of America
PMID: 36001689

Abstract

The next robotics frontier will be led by biohybrids. Capable biohybrid robots require microfluidics to sustain, improve, and scale the architectural complexity of their core ingredient: biological tissues. Advances in microfluidics have already revolutionized disease modeling and drug development, and are positioned to impact regenerative medicine but have yet to apply to biohybrids. Fusing microfluidics with living materials will improve tissue perfusion and maturation, and enable precise patterning of sensing, processing, and control elements. This perspective suggests future developments in advanced biohybrids.

Authors

  • Miriam Filippi
    Soft Robotics Laboratory, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
  • Oncay Yasa
    Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.
  • Roger Dale Kamm
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Ritu Raman
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Robert K Katzschmann
    Soft Robotics Laboratory, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.

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