AIMC Topic: Microfluidics

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A Machine Learning-Driven Electrophysiological Platform for Real-Time Tumor-Neural Interaction Analysis and Modulation.

Nature communications
Neural-tumor electrophysiology-marked by pathological membrane potentials and ion channel dysregulation-emerges as actionable targets to curb tumor aggression. Yet, how neural-driven bioelectrical crosstalk dynamically regulates tumors within functio...

Self-Powered Gravity Domino Microfluidics for Rapid At-Home Immunoassays with Artificial Intelligence.

ACS nano
At-home testing facilitates early screening and longitudinal monitoring of immune disorders, significantly enhancing patient engagement in personalized healthcare management. This convenient self-testing capability primarily stems from advancements i...

Advances in machine learning-enhanced microfluidic cell sorting.

Science advances
Cell sorting, essential for diagnostics and early intervention, has evolved from conventional methods to sophisticated microfluidic approaches. These miniaturized systems leverage precise hydrodynamic control, facilitating major advances in tumor cel...

Microfluidics-based fabrication and targeted motion control of multimodal therapeutic hydrogel capsule microrobots.

Journal of materials chemistry. B
In cancer combination therapy, micro-robot systems that integrate multiple therapeutic functions have emerged as a key direction for overcoming the limitations of traditional treatments. This study proposes a magnetic thermosensitive hydrogel capsule...

Transforming microfluidics for single-cell analysis with robotics and artificial intelligence.

Lab on a chip
Single-cell analysis has advanced biomedical research by revealing cellular heterogeneity with unprecedented resolution, identifying rare subpopulations that drive disease progression and therapeutic resistance. Microfluidics is central to this advan...

Machine Learning-Guided microfluidic optimization of clinically inspired liposomes for nanomedicine applications.

International journal of pharmaceutics
Liposomes have transformed drug delivery by enhancing the solubility, stability, and bioavailability of therapeutic agents, driving widespread clinical adoption and contributing to a rapidly expanding multi-billion-dollar market. However, despite the...

Self-regulating microfluidic system for lipid nanoparticle production.

Journal of controlled release : official journal of the Controlled Release Society
Lipid nanoparticles have emerged as valuable gene delivery systems paving the way for next-generation vaccine and cancer therapeutics. Inevitably, this evolution is carried by dissecting and rationalizing the vehicles' complex formulation process. Gi...

Intelligence prediction of microfluidically prepared nanoparticles.

Scientific reports
Developing poly(lactic-co-glycolic) acid (PLGA) nanoparticles with optimized drug encapsulation and loading is crucial for effective drug delivery. However, controlling the physicochemical properties of these nanoparticles remains challenging. In thi...

Microfluidic-based nanocarriers for overcoming biological barriers in therapeutic delivery systems.

Nanoscale
Microfluidic technologies have revolutionized the synthesis of nanocarriers for drug and gene delivery, providing unparalleled precision and efficiency in the production of therapeutic nanoparticles. This review highlights recent advancements in micr...

Rapid label-free identification of seven bacterial species using microfluidics, single-cell time-lapse phase-contrast microscopy, and deep learning-based image and video classification.

PloS one
For effective treatment of bacterial infections, it is essential to identify the species causing the infection as early as possible. Current methods typically require hours of overnight culturing of a bacterial sample and a larger quantity of cells t...