Application of the sliding window method and Mask-RCNN method to nuclear recognition in oral cytology.

Journal: Diagnostic pathology
Published Date: Aug 2, 2022

Abstract

BACKGROUND: We aimed to develop an artificial intelligence (AI)-assisted oral cytology method, similar to cervical cytology. We focused on the detection of cell nuclei because the ratio of cell nuclei to cytoplasm increases with increasing cell malignancy. As an initial step in the development of AI-assisted cytology, we investigated two methods for the automatic detection of cell nuclei in blue-stained cells in cytopreparation images.

Authors

  • Eiji Mitate
    Department of Oral Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki-City, 852-8501, Japan. mitateeiji@gmail.com.
  • Kirin Inoue
    Mechanical Engineering Program, Department of Advanced Engineering, Nagasaki University Graduate School of Engineering, 1-14, Bunkyo-machi, Nagasaki City, 852-8521, Japan.
  • Retsushi Sato
    Mechanical Engineering Program, Department of Advanced Engineering, Nagasaki University Graduate School of Engineering, 1-14, Bunkyo-machi, Nagasaki City, 852-8521, Japan.
  • Youichi Shimomoto
    Nagasaki University Graduate School of Engineering, 1-14, Bunkyo-machi, Nagasaki City, 852-8521, Japan.
  • Seigo Ohba
    Department of Regenerative Oral Surgery, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki City, 852-8501, Japan.
  • Kinuko Ogata
    Department of Regenerative Oral Surgery, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki City, 852-8501, Japan.
  • Tomoya Sakai
    Department of Complexity Science and Engineering, The University of Tokyo, Japan; Center for Advanced Intelligence Project, RIKEN, Japan. Electronic address: sakai@ms.k.u-tokyo.ac.jp.
  • Jun Ohno
    Research Center for Regenerative Medicine, Fukuoka Dental College, 2-15-1, Tamura, Sawara-ku, Fukuoka City, 814-0193, Japan.
  • Ikuo Yamamoto
    Graduate School of Engineering, Nagasaki University, Nagasaki, Japan.
  • Izumi Asahina
    Department of Regenerative Oral Surgery, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki City, 852-8501, Japan.

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