GNN-SubNet: disease subnetwork detection with explainable graph neural networks.

Journal: Bioinformatics (Oxford, England)
Published Date: Sep 16, 2022

Abstract

MOTIVATION: The tremendous success of graphical neural networks (GNNs) already had a major impact on systems biology research. For example, GNNs are currently being used for drug target recognition in protein-drug interaction networks, as well as for cancer gene discovery and more. Important aspects whose practical relevance is often underestimated are comprehensibility, interpretability and explainability.

Authors

  • Bastian Pfeifer
    Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria.
  • Anna Saranti
    Human-Centered AI Lab, Institute of Forest Engineering, Department of Forest and Soil Sciences, University of Natural Resources and Life Sciences Vienna, 1190 Wien, Austria.
  • Andreas Holzinger
    Human-Centered AI Lab, Medical University of Graz, Graz, Austria.

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