Deterministic small-scale undulations of image-based risk predictions from the deep learning of lung tumors in motion.

Journal: Medical physics
Published Date:

Abstract

INTRODUCTION: Deep learning (DL) models that use medical images to predict clinical outcomes are poised for clinical translation. For tumors that reside in organs that move, however, the impact of motion (i.e., degenerated object appearance or blur) on DL model accuracy remains unclear. We examine the impact of tumor motion on an image-based DL framework that predicts local failure risk after lung stereotactic body radiotherapy (SBRT).

Authors

  • P Troy Teo
    Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Amishi Bajaj
    Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • James Randall
    Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Bin Lou
    755 College Road East, Digital Technology and Innovation Division, Siemens Healthineers, Princeton, NJ, 08540.
  • Jainil Shah
    Diagnostic Imaging Computed Tomography, Siemens Healthineers, Malvern, Pennsylvania, USA.
  • Mahesh Gopalakrishnan
    Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
  • Ali Kamen
    755 College Road East, Digital Technology and Innovation Division, Siemens Healthineers, Princeton, NJ, 08540.
  • Mohamed E Abazeed
    2111 East 96th St/NE-6, Department of Translational Hematology Oncology Research, Cleveland Clinic, Cleveland, OH, 44195.