MOOD 2020: A Public Benchmark for Out-of-Distribution Detection and Localization on Medical Images.

Journal: IEEE transactions on medical imaging
Published Date:

Abstract

Detecting Out-of-Distribution (OoD) data is one of the greatest challenges in safe and robust deployment of machine learning algorithms in medicine. When the algorithms encounter cases that deviate from the distribution of the training data, they often produce incorrect and over-confident predictions. OoD detection algorithms aim to catch erroneous predictions in advance by analysing the data distribution and detecting potential instances of failure. Moreover, flagging OoD cases may support human readers in identifying incidental findings. Due to the increased interest in OoD algorithms, benchmarks for different domains have recently been established. In the medical imaging domain, for which reliable predictions are often essential, an open benchmark has been missing. We introduce the Medical-Out-Of-Distribution-Analysis-Challenge (MOOD) as an open, fair, and unbiased benchmark for OoD methods in the medical imaging domain. The analysis of the submitted algorithms shows that performance has a strong positive correlation with the perceived difficulty, and that all algorithms show a high variance for different anomalies, making it yet hard to recommend them for clinical practice. We also see a strong correlation between challenge ranking and performance on a simple toy test set, indicating that this might be a valuable addition as a proxy dataset during anomaly detection algorithm development.

Authors

  • David Zimmerer
    Medical Image Computing, German Cancer Research Center, Im Neuenheimer Feld 581, 69210, Heidelberg, Germany.
  • Peter M Full
  • Fabian Isensee
  • Paul Jager
  • Tim Adler
  • Jens Petersen
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany; Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Gregor Kohler
  • Tobias Roß
    German Cancer Research Center (DKFZ), Computer Assisted Medical Interventions, Heidelberg, Germany.
  • Annika Reinke
    German Cancer Research Center DKFZ, Division of Computer Assisted Medical Interventions, Heidelberg, Germany. Electronic address: a.reinke@dkfz.de.
  • Antanas Kascenas
  • Bjørn Sand Jensen
    School of Computing Science, University of Glasgow, Glasgow, Scotland.
  • Alison Q O'Neil
    School of Engineering, The University of Edinburgh, Edinburgh EH9 3FG, UK; Canon Medical Research Europe, Edinburgh EH6 5NP, UK.
  • Jeremy Tan
  • Benjamin Hou
    Biomedical Image Analysis Group (BioMedIA), Imperial College London, London, UK.
  • James Batten
  • Huaqi Qiu
  • Bernhard Kainz
    Biomedical Image Analysis (BioMedIA) Group, Department of Computing, Imperial College London, UK.
  • Nina Shvetsova
  • Irina Fedulova
  • Dmitry V Dylov
    Center of Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow, Russia (A.M.Z., E.A.I., M.V.F., D.V.D.).
  • Baolun Yu
  • Jianyang Zhai
  • Jingtao Hu
  • Runxuan Si
  • Sihang Zhou
    Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA; School of Computer, National University of Defense Technology, Changsha, China.
  • Siqi Wang
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, People's Republic of China.
  • Xinyang Li
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Xuerun Chen
  • Yang Zhao
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Sergio Naval Marimont
  • Giacomo Tarroni
    Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, UK.
  • Victor Saase
  • Lena Maier-Hein
    German Cancer Research Center (DKFZ), Computer Assisted Medical Interventions, Heidelberg, Germany.
  • Klaus Maier-Hein
    Medical Image Analysis, Division Medical Image Computing, DKFZ Heidelberg, Germany.