Development and validation of a deep-learning model for detecting brain metastases on 3D post-contrast MRI: a multi-center multi-reader evaluation study.

Journal: Neuro-oncology
Published Date:

Abstract

BACKGROUND: Accurate detection is essential for brain metastasis (BM) management, but manual identification is laborious. This study developed, validated, and evaluated a BM detection (BMD) system.

Authors

  • Shaohan Yin
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Xiao Luo
    Department of Spine Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China.
  • Yadi Yang
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Ying Shao
  • Lidi Ma
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Cuiping Lin
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Qiuxia Yang
    Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
  • Deling Wang
    Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
  • Yingwei Luo
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Zhijun Mai
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Weixiong Fan
    Department of Magnetic Resonance, Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital, Meizhou, China.
  • Dechun Zheng
    Department of Radiology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
  • Jianpeng Li
    Department of Cardiology, Taizhou Second People's Hospital, The Affiliated Taizhou Second People's Hospital of Yangzhou University, Taizhou, China.
  • Fengyan Cheng
    Department of Magnetic Resonance, Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital, Meizhou, China.
  • Yuhui Zhang
    Department of Mathematical and Computing Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan. Electronic address: zhang.y.av@m.titech.ac.jp.
  • Xinwei Zhong
    Department of Magnetic Resonance, Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital, Meizhou, China.
  • Fangmin Shen
    Department of Radiology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
  • Guohua Shao
    Department Of Radiology, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, China.
  • Jiahao Wu
  • Ying Sun
    CFAR and I2R, Agency for Science, Technology and Research, Singapore.
  • Huiyan Luo
    Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Chaofeng Li
    State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, P. R. China.
  • Yaozong Gao
  • Dinggang Shen
    School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
  • Rong Zhang
    Internal Medicine - Cardiology Division, UT Southwestern, Dallas, TX, USA.
  • Chuanmiao Xie
    Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.