Disease classification for whole-blood DNA methylation: Meta-analysis, missing values imputation, and XAI.

Journal: GigaScience
Published Date: Oct 19, 2022

Abstract

BACKGROUND: DNA methylation has a significant effect on gene expression and can be associated with various diseases. Meta-analysis of available DNA methylation datasets requires development of a specific workflow for joint data processing.

Authors

  • Alena Kalyakulina
    Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
  • Igor Yusipov
    Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
  • Maria Giulia Bacalini
    IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
  • Claudio Franceschi
    Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky University, Nizhny, Russia.
  • Maria Vedunova
    Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhniy Novgorod, Nizhniy Novgorod, Russia.
  • Mikhail Ivanchenko
    Institute of Information Technology, Mathematics and Mechanics, National Research Lobachevsky State University of Nizhniy Novgorod, Nizhniy Novgorod, Russia.

Keywords

External Resources

Popular Topics
Recent Journals