Development and Validation of a Deep Learning Model for Predicting Treatment Response in Patients With Newly Diagnosed Epilepsy.

Journal: JAMA neurology
Published Date:

Abstract

IMPORTANCE: Selection of antiseizure medications (ASMs) for epilepsy remains largely a trial-and-error approach. Under this approach, many patients have to endure sequential trials of ineffective treatments until the "right drugs" are prescribed.

Authors

  • Haris Hakeem
    Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
  • Wei Feng
    Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, You'anmenwai, Xitoutiao No.10, Beijing, P. R. China.
  • Zhibin Chen
    Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
  • Jiun Choong
    Department of Electrical and Computer Systems Engineering, Monash University, Clayton, Victoria, Australia.
  • Martin J Brodie
    Department of Medicine and Clinical Pharmacology, University of Glasgow, Glasgow, Scotland.
  • Si-Lei Fong
    Neurology Division, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Kheng-Seang Lim
    Neurology Division, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Junhong Wu
    Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China.
  • Xuefeng Wang
    Department of Advanced Manufacturing and Robotics, College of Engineering, Peking University, Beijing 100871, China.
  • Nicholas Lawn
    WA Adult Epilepsy Service, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
  • Guanzhong Ni
    Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Xiang Gao
    Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
  • Mijuan Luo
    Department of Pharmacy, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Ziyi Chen
    Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China.
  • Zongyuan Ge
    AIM for Health Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia; Monash-Airdoc Research Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia.
  • Patrick Kwan