Pattern recognition of topologically associating domains using deep learning.
Journal:
BMC bioinformatics
Published Date:
Dec 8, 2022
Abstract
BACKGROUND: Recent increasing evidence indicates that three-dimensional chromosome structure plays an important role in genomic function. Topologically associating domains (TADs) are self-interacting regions that have been shown to be a chromosomal structural unit. During evolution, these are conserved based on checking synteny block cross species. Are there common TAD patterns across species or cell lines?