AIMC Topic: Mice

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Machine learning-based integration identifies plasma cells-related gene signature ST6GAL1 in idiopathic pulmonary fibrosis.

BMC pulmonary medicine Jul 2, 2025
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare, progressive, and fibrotic disease with poor prognosis that lacks treatment options. As a major component of the lung adaptive immune system, plasma cells play a crucial regulatory role during...
Mice Idiopathic Pulmonary Fibrosis Plasma Cells Sialyltransferases Animals Male Gene Expression Profiling Transcriptome Humans Machine Learning Prognosis Female Aged
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Ensemble methods and partially-supervised learning for accurate and robust automatic murine organ segmentation.

Scientific reports Jul 2, 2025
Delineation of multiple organs in murine µCT images is crucial for preclinical studies but requires manual volumetric segmentation, a tedious and time-consuming process prone to inter-observer variability. Automatic deep learning-based segmentation c...
Image Processing, Computer-Assisted Reproducibility of Results Mice Animals Supervised Machine Learning Deep Learning X-Ray Microtomography Imaging, Three-Dimensional
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Integrating machine learning and bioinformatics approaches to identify novel diagnostic gene biomarkers for diabetic mice.

Scientific reports Jul 2, 2025
Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding ...
Databases, Genetic HMGB1 Protein Diabetes Mellitus, Experimental Sirtuin 1 Gene Ontology Protein Interaction Maps Gene Regulatory Networks Machine Learning Mice Computational Biology Biomarkers Animals Gene Expression Profiling
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Machine learning-assisted decoding of temporal transcriptional dynamics via fluorescent timer.

Nature communications Jul 1, 2025
Investigating the temporal dynamics of gene expression is crucial for understanding gene regulation across various biological processes. Using the Fluorescent Timer protein, the Timer-of-cell-kinetics-and-activity system enables analysis of transcrip...
Flow Cytometry Forkhead Transcription Factors T-Lymphocytes, Regulatory Single-Cell Analysis Neural Networks, Computer Spleen Gene Expression Regulation Mice Machine Learning Transcription, Genetic Mice, Inbred C57BL Animals Enhancer Elements, Genetic CRISPR-Cas Systems Genes, Reporter
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Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes.

Scientific reports Jul 1, 2025
These studies aimed to study the mechanisms of glaucomatous peripapillary scleral (PPS) remodeling by investigating IOP-induced changes in fibroblast actin-collagen alignment and nuclear morphology in mouse PPS. Cryosections from the optic nerve head...
Male Mice Disease Models, Animal Cytoskeleton Mice, Inbred C57BL Fibroblasts Glaucoma Ocular Hypertension Collagen Intraocular Pressure Sclera Optic Disk Animals Actins
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Deep learning-driven drug response prediction and mechanistic insights in cancer genomics.

Scientific reports Jul 1, 2025
In the field of cancer therapy, the diversity and heterogeneity of cancer genomes in clinical patients complicate and challenge the effective use of non-targeted drugs, as these drugs often fail to address specific genetic events. Recent advancements...
Humans Animals Neoplasms Apoptosis Xenograft Model Antitumor Assays Piperidines Drug Resistance, Neoplasm Protein Kinase Inhibitors Mice Adenine Antineoplastic Agents Genomics Deep Learning Gene Expression Regulation, Neoplastic Cell Line, Tumor Cell Proliferation
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Deep-learning-based automated prediction of mouse seminiferous tubule stage by using bright-field microscopy.

Scientific reports Jul 1, 2025
Infertility is a global issue, and approximately 50% of cases are due to male factors, with defective spermatogenesis being the main one. For studies of spermatogenesis, evaluating the seminiferous tubule stage is essential. However, current evaluati...
Mice Microscopy Spermatogenesis Seminiferous Tubules Male Deep Learning Image Processing, Computer-Assisted Reproducibility of Results Animals
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Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy.

Nature communications Jul 1, 2025
Metabolic homeostasis requires engagement of catabolic and anabolic pathways consuming nutrients that generate and consume energy and biomass. Our current understanding of cell homeostasis and metabolism, including how cells utilize nutrients, comes ...
Endoplasmic Reticulum Glycogen Carbon Isotopes Lipid Droplets Humans Animals Male Mice Glucose Mitochondria Hepatocytes Microscopy
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Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice.

Nature communications Jul 1, 2025
Brainstem noradrenaline (NA) neurons modulate the activity of many neural networks including those responsible for the control of fertility. Using brain slice electrophysiology, we demonstrate that the arcuate nucleus kisspeptin (ARN) neurons, recent...
Female Animals Male Gonadotropin-Releasing Hormone Kisspeptins Brain Stem Locus Coeruleus Mice Mice, Inbred C57BL Norepinephrine Neurons Arcuate Nucleus of Hypothalamus Adrenergic Neurons
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A simplified minimodel of visual cortical neurons.

Nature communications Jul 1, 2025
Artificial neural networks (ANNs) have been shown to predict neural responses in primary visual cortex (V1) better than classical models. However, this performance often comes at the expense of simplicity and interpretability. Here we introduce a new...
Photic Stimulation Visual Cortex Primary Visual Cortex Animals Mice Models, Neurological Neurons Neural Networks, Computer
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