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BMC biology
40350411
BACKGROUND: Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-protein complexes known as rod-ring (RR) structures t...
Genome biology
40340964
BACKGROUND: Adenine base editors (ABEs) enable the conversion of A•T to G•C base pairs. Since the sequence of the target locus influences base editing efficiency, efforts have been made to develop computational models that can predict base editing ou...
Drug design, development and therapy
40291160
PURPOSE: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.
Parasites & vectors
40355954
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumatic disease. The recently approved CHIKV vaccine, IXCHIQ, is based on a live-attenuated CHIKV strain ...
PloS one
40299871
It is well established that the early inflammatory response following fracture is essential for initiating subsequent bone regeneration. An imbalance in inflammation, whether within the innate or adaptive immune response, can result in impaired fract...
The Journal of international medical research
40287984
BackgroundKnee osteoarthritis is a debilitating disease with a complex pathogenesis. Synovitis, which refers to inflammation of the synovial membrane surrounding the joint, is believed to play an important role in the development and progression of k...
Scientific reports
40341694
The safety and efficacy of irreversible electroporation (IRE) in tumor therapy has been validated over many years by clinical application. An in-depth study, however, is required to assess the degree of ablation during the clinical dissemination of t...
eLife
40326557
Deep learning-based methods have advanced animal pose estimation, enhancing accuracy, and efficiency in quantifying animal behavior. However, these methods frequently experience tracking drift, where noise-induced jumps in body point estimates compro...
Scientific reports
40374840
Diabetes mellitus (DM) is a chronic metabolic disorder that poses significant challenges to public health. Among its various complications, diabetic nephropathy (DN) emerges as a critical microvascular complication associated with high mortality rate...
Cell death & disease
40382332
Ferroptosis is a recently described type of regulated necrotic cell death whose induction has anti-cancer therapeutic potential, especially in hematological malignancies. However, efforts to uncover novel ferroptosis-inducing therapeutics have been l...