Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments.

Journal: Transplant international : official journal of the European Society for Organ Transplantation
Published Date:

Abstract

The Banff Digital Pathology Working Group (DPWG) was established with the goal to establish a digital pathology repository; develop, validate, and share models for image analysis; and foster collaborations using regular videoconferencing. During the calls, a variety of artificial intelligence (AI)-based support systems for transplantation pathology were presented. Potential collaborations in a competition/trial on AI applied to kidney transplant specimens, including the DIAGGRAFT challenge (staining of biopsies at multiple institutions, pathologists' visual assessment, and development and validation of new and pre-existing Banff scoring algorithms), were also discussed. To determine the next steps, a survey was conducted, primarily focusing on the feasibility of establishing a digital pathology repository and identifying potential hosts. Sixteen of the 35 respondents (46%) had access to a server hosting a digital pathology repository, with 2 respondents that could serve as a potential host at no cost to the DPWG. The 16 digital pathology repositories collected specimens from various organs, with the largest constituent being kidney ( = 12,870 specimens). A DPWG pilot digital pathology repository was established, and there are plans for a competition/trial with the DIAGGRAFT project. Utilizing existing resources and previously established models, the Banff DPWG is establishing new resources for the Banff community.

Authors

  • Alton B Farris
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Mariam P Alexander
    William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota; and.
  • Ulysses G J Balis
    Department of Pathology, University of Michigan, Ann Arbor, Michigan.
  • Laura Barisoni
    Department of Pathology and Medicine, Division of Nephrology, Duke University, Durham, North Carolina, USA.
  • Peter Boor
    Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
  • Roman D Bülow
    Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
  • Lynn D Cornell
    Department of Laboratory Medicine and Pathology, Mayo Clinic - Rochester, Rochester, MN, USA.
  • Anthony J Demetris
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States.
  • Evan Farkash
    Department of Pathology, University of Michigan, Ann Arbor, MI, United States.
  • Meyke Hermsen
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Julien Hogan
    Pediatric Nephrology Department, Robert Debré Hospital, 48 Boulevard Sérurier, 75019, Paris, France.
  • Renate Kain
    Department of Pathology, Medical University of Vienna, Vienna, Austria.
  • Jesper Kers
    Department of Pathology, Amsterdam Infection & Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, and.
  • Jun Kong
    Stony Brook University, Stony Brook, NY.
  • Richard M Levenson
    Department of Pathology, University of California Davis Health System, Sacramento, CA, United States.
  • Alexandre Loupy
    Hôpital Necker, Paris, France.
  • Maarten Naesens
    Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
  • Pinaki Sarder
  • John E Tomaszewski
    Department of Pathology, The State University of New York at Buffalo, Buffalo, NY, United States.
  • Jeroen van der Laak
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Dominique van Midden
    Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands.
  • Yukako Yagi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Kim Solez
    Department of Pathology, University of Alberta, Edmonton, AB, Canada.