This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Living kidney donors typically experience approximately a 30% reduction in kidney function after donation, although the degree of reduction varies among individuals. This study aimed to develop a machine learning (ML) model to predict serum creatinin...
Tissue atlases provide foundational knowledge on the cellular organization and molecular distributions across molecular classes and spatial scales. Here, we construct a comprehensive spatiomolecular lipid atlas of the human kidney from 29 donor tissu...
Although iron is an essential element for vital body functions, iron overload (IO) is accompanied by significant cellular damage due to its accumulation within organs. Thus, early diagnosis and accurate identification of the affected organs are criti...
Over the past few decades, the rising burden of metabolic disease, including type 2 diabetes, prediabetes, obesity, and metabolic dysfunction-associated steatotic liver disease, has corresponded with fundamental shifts in the landscape of heart failu...
The joint use of multiple modalities for medical image processing has been widely studied in recent years. The fusion of information from different modalities has demonstrated the performance improvement for a lot of medical tasks. For nephropathy di...
OBJECTIVE: Kidney fibrosis is a key pathological feature in the progression of chronic kidney disease (CKD), traditionally diagnosed through invasive kidney biopsy. This study aimed to develop and validate a noninvasive, multi-center predictive model...
Membranous nephropathy (MN) is one of the most common glomerular diseases. Although the diagnostic method based on serum PLA2R antibodies has gradually been applied in clinical practice, only 52-86% of PLA2R-associated MN patients show positive anti-...
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Prunus persica (L.) Batsch (peach) exhibit medicinal properties and are utilized in traditional Chinese medicine (TCM) for therapeutic purposes. Notably, the root of P. persica, referred to as "taoshug...
The kidney plays a vital role in maintaining homeostasis, but lifestyle factors and diseases can lead to kidney failures. Early detection of kidney disease is crucial for effective intervention, often challenging due to unnoticeable symptoms in the i...
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