Small immunological clocks identified by deep learning and gradient boosting.

Journal: Frontiers in immunology
Published Date: Aug 25, 2023

Abstract

BACKGROUND: The aging process affects all systems of the human body, and the observed increase in inflammatory components affecting the immune system in old age can lead to the development of age-associated diseases and systemic inflammation.

Authors

  • Alena Kalyakulina
    Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
  • Igor Yusipov
    Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.
  • Elena Kondakova
    Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhniy Novgorod, Nizhniy Novgorod, Russia.
  • Maria Giulia Bacalini
    IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
  • Claudio Franceschi
    Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky University, Nizhny, Russia.
  • Maria Vedunova
    Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhniy Novgorod, Nizhniy Novgorod, Russia.
  • Mikhail Ivanchenko
    Institute of Information Technology, Mathematics and Mechanics, National Research Lobachevsky State University of Nizhniy Novgorod, Nizhniy Novgorod, Russia.

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