AIMC Topic: Inflammation
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Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation.
BMC pharmacology & toxicology
Aug 4, 2025
BACKGROUND: Nonspecific orbital inflammation (NSOI), also known as idiopathic orbital inflammation, comprises a heterogeneous group of immune-mediated disorders affecting orbital tissues, unified by the absence of a defined etiology. Lactotransferrin...
Prediction of hub genes in pulpal inflammation and regeneration using autoencoders and a generative AI approach.
Scientific reports
Jul 19, 2025
Pulpal inflammation and regeneration are crucial for enhancing endodontic treatment outcomes. Transcriptomic studies highlight the involvement of proinflammatory cytokines, NF-κB signaling, and stem cell activity. This study employs a generative AI a...
StackPIP: An Effective Computational Framework for Accurate and Balanced Identification of Proinflammatory Peptides.
Journal of chemical information and modeling
Jul 10, 2025
Proinflammatory peptides (PIPs) play a crucial role in immune response modulation by orchestrating cytokine release and leukocyte recruitment. Accurate identification of PIPs is essential for understanding inflammation-related diseases and developing...
Inflammatory, fibrotic and endothelial biomarker profiles in COVID-19 patients during and following hospitalization.
Scientific reports
Jul 10, 2025
Survivors of severe COVID-19 often suffer from long-term respiratory issues, but the molecular drivers of this damage remain unclear. This study explored the dynamics of inflammatory, fibrotic, and endothelial biomarkers in hospitalized COVID-19 pati...
Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches.
Nutrition journal
Jul 7, 2025
BACKGROUND: To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome.
Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients.
Cardiovascular diabetology
Jul 3, 2025
BACKGROUND: Coronary Heart Disease (CHD) and Non-Alcoholic Fatty Liver Disease (NAFLD) share overlapping pathogenic mechanisms including adipose tissue dysfunction, insulin resistance, and systemic inflammation mediated by adipokines. However, the sp...
Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.
NPJ biofilms and microbiomes
Jul 1, 2025
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...
Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.
Cardiovascular diabetology
Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
Coronary Artery Disease
Reproducibility of Results
Inflammation Mediators
Aged
5-Methylcytosine
Male
Middle Aged
Machine Learning
Humans
DNA Methylation
Risk Assessment
Biomarkers
Non-ST Elevated Myocardial Infarction
Severity of Illness Index
Prognosis
Predictive Value of Tests
Cell-Free Nucleic Acids
Epigenesis, Genetic
Female
ST Elevation Myocardial Infarction
Inflammation
Relationship between amino acid metabolism and inflammation in coronary heart disease (Review).
International journal of molecular medicine
Jun 6, 2025
This review delves into the intricate relationship between amino acid metabolism and inflammation in coronary heart disease (CHD). Research shows that disruptions in the metabolism of arginine, glutamate, branched‑chain amino acids (BCAAs) and trypto...
Machine learning based gut microbiota pattern and response to fiber as a diagnostic tool for chronic inflammatory diseases.
BMC microbiology
Jun 6, 2025
Gut microbiota has been implicated in the pathogenesis of multiple gastrointestinal (GI) and systemic metabolic and inflammatory disorders where disrupted gut microbiota composition and function (dysbiosis) has been found in multiple studies. Thus, h...
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