PlexusNet: A neural network architectural concept for medical image classification.

Journal: Computers in biology and medicine
Published Date:

Abstract

State-of-the-art (SOTA) convolutional neural network models have been widely adapted in medical imaging and applied to address different clinical problems. However, the complexity and scale of such models may not be justified in medical imaging and subject to the available resource budget. Further increasing the number of representative feature maps for the classification task decreases the model explainability. The current data normalization practice is fixed prior to model development and discounting the specification of the data domain. Acknowledging these issues, the current work proposed a new scalable model family called PlexusNet; the block architecture and model scaling by the network's depth, width, and branch regulate PlexusNet's architecture. The efficient computation costs outlined the dimensions of PlexusNet scaling and design. PlexusNet includes a new learnable data normalization algorithm for better data generalization. We applied a simple yet effective neural architecture search to design PlexusNet tailored to five clinical classification problems that achieve a performance noninferior to the SOTA models ResNet-18 and EfficientNet B0/1. It also does so with lower parameter capacity and representative feature maps in ten-fold ranges than the smallest SOTA models with comparable performance. The visualization of representative features revealed distinguishable clusters associated with categories based on latent features generated by PlexusNet. The package and source code are at https://github.com/oeminaga/PlexusNet.git.

Authors

  • Okyaz Eminaga
    Okyaz Eminaga, Stanford Medical School, Stanford, CA; University Hospital of Cologne, Cologne, France; Nurettin Eminaga, St Mauritius Therapy Clinic, Meerbusch; Axel Semjonow, University Hospital Muenster; and Bernhard Breil, Niederrhein University of Applied Sciences, Krefeld, Germany.
  • Mahmoud Abbas
    Department of Pathology, University of Muenster, Muenster, Germany. Electronic address: mahabbas74@googlemail.com.
  • Jeanne Shen
    Center for Artificial Intelligence in Medicine and Imaging, Stanford University, 1701 Page Mill Road, Palo Alto, CA, 94304, USA. jeannes@stanford.edu.
  • Mark Laurie
    Department of Computer Science, Stanford University, Stanford, CA, 94305, USA. Electronic address: markl21@stanford.edu.
  • James D Brooks
    Department of Urology, Stanford School of Medicine, CA.
  • Joseph C Liao
    Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.
  • Daniel L Rubin
    Department of Biomedical Data Science, Stanford University School of Medicine Medical School Office Building, Stanford CA 94305-5479.