Paragraph-antibody paratope prediction using graph neural networks with minimal feature vectors.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Jan 1, 2023
Abstract
SUMMARY: The development of new vaccines and antibody therapeutics typically takes several years and requires over $1bn in investment. Accurate knowledge of the paratope (antibody binding site) can speed up and reduce the cost of this process by improving our understanding of antibody-antigen binding. We present Paragraph, a structure-based paratope prediction tool that outperforms current state-of-the-art tools using simpler feature vectors and no antigen information.