Speed-resolved perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning.

Journal: Journal of biomedical optics
PMID: 36950019

Abstract

SIGNIFICANCE: Laser speckle contrast imaging (LSCI) gives a relative measure of microcirculatory perfusion. However, due to the limited information in single-exposure LSCI, models are inaccurate for skin tissue due to complex effects from e.g. static and dynamic scatterers, multiple Doppler shifts, and the speed-distribution of blood. It has been demonstrated how to account for these effects in laser Doppler flowmetry (LDF) using inverse Monte Carlo (MC) algorithms. This allows for a speed-resolved perfusion measure in absolute units %RBC × mm/s, improving the physiological interpretation of the data. Until now, this has been limited to a single-point LDF technique but recent advances in multi-exposure LSCI (MELSCI) enable the analysis in an imaging modality.

Authors

  • Martin Hultman
    Linköping University, Department of Biomedical Engineering, Linköping, Sweden.
  • Marcus Larsson
    Linköping University, Department of Biomedical Engineering, Linköping, Sweden.
  • Tomas Strömberg
    Linköping University, Department of Biomedical Engineering, Linköping, Sweden.
  • Ingemar Fredriksson
    Linköping University, Department of Biomedical Engineering, Linköping, Sweden.

Keywords

External Resources

Popular Topics
Recent Journals