An easy-to-use artificial intelligence preoperative lymph node metastasis predictor (LN-MASTER) in rectal cancer based on a privacy-preserving computing platform: multicenter retrospective cohort study.

Journal: International journal of surgery (London, England)
Published Date: Mar 1, 2023

Abstract

BACKGROUND: Although the surgical treatment strategy for rectal cancer (RC) is usually based on the preoperative diagnosis of lymph node metastasis (LNM), the accurate diagnosis of LNM has been a clinical challenge. In this study, we developed machine learning (ML) models to predict the LNM status before surgery based on a privacy-preserving computing platform (PPCP) and created a web tool to help clinicians with treatment-based decision-making in RC patients.

Authors

  • Xu Guan
    College of Information Science and Engineering, Ocean University of China, Qingdao, China. guanxu@stu.ouc.edu.cn.
  • Guanyu Yu
    Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai.
  • Weiyuan Zhang
    Department of Colorectal Cancer Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Rongbo Wen
    Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai.
  • Ran Wei
  • Shuai Jiao
    Department of Colorectal Cancer Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Qing Zhao
    Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Zheng Lou
    Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai.
  • Liqiang Hao
    Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai.
  • Enrui Liu
    Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
  • Xianhua Gao
    Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai.
  • Guiyu Wang
    Department of Colorectal Cancer Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Xishan Wang
    Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.

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