Review on deep learning fetal brain segmentation from Magnetic Resonance images.

Journal: Artificial intelligence in medicine
PMID:

Abstract

Brain segmentation is often the first and most critical step in quantitative analysis of the brain for many clinical applications, including fetal imaging. Different aspects challenge the segmentation of the fetal brain in magnetic resonance imaging (MRI), such as the non-standard position of the fetus owing to his/her movements during the examination, rapid brain development, and the limited availability of imaging data. In recent years, several segmentation methods have been proposed for automatically partitioning the fetal brain from MR images. These algorithms aim to define regions of interest with different shapes and intensities, encompassing the entire brain, or isolating specific structures. Deep learning techniques, particularly convolutional neural networks (CNNs), have become a state-of-the-art approach in the field because they can provide reliable segmentation results over heterogeneous datasets. Here, we review the deep learning algorithms developed in the field of fetal brain segmentation and categorize them according to their target structures. Finally, we discuss the perceived research gaps in the literature of the fetal domain, suggesting possible future research directions that could impact the management of fetal MR images.

Authors

  • Tommaso Ciceri
    NeuroImaging Laboratory, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Italy; Department of Information Engineering, University of Padua, Padua, Italy.
  • Letizia Squarcina
    UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Italy; InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy.
  • Alice Giubergia
    NeuroImaging Laboratory, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Italy; Department of Information Engineering, University of Padua, Padua, Italy.
  • Alessandra Bertoldo
    Department of Information Engineering, University of Padua, Padua, Italy; University of Padua, Padova Neuroscience Center, Padua, Italy.
  • Paolo Brambilla
    Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, TX, USA. Electronic address: paolo.brambilla1@unimi.it.
  • Denis Peruzzo
    Neuroimaging Unit, Scientific Institute IRCCS "Eugenio Medea", Bosisio Parini (Lecco), Italy; Department of Computer Science, University of Verona, Verona, Italy. Electronic address: denis.peruzzo@lanostrafamiglia.it.