Aligned deep neural network for integrative analysis with high-dimensional input.
Journal:
Journal of biomedical informatics
Published Date:
Jun 28, 2023
Abstract
OBJECTIVE: Deep neural network (DNN) techniques have demonstrated significant advantages over regression and some other techniques. In recent studies, DNN-based analysis has been conducted on data with high-dimensional input such as omics measurements. In such analysis, regularization, in particular penalization, has been applied to regularize estimation and distinguish relevant input variables from irrelevant ones. A unique challenge arises from the "lack of information" attributable to high dimensionality of input and limited size of training data. For many data/studies, there exist other data/studies that may be relevant and can potentially provide additional information to boost performance.