Integrating domain knowledge for biomedical text analysis into deep learning: A survey.

Journal: Journal of biomedical informatics
Published Date:

Abstract

The past decade has witnessed an explosion of textual information in the biomedical field. Biomedical texts provide a basis for healthcare delivery, knowledge discovery, and decision-making. Over the same period, deep learning has achieved remarkable performance in biomedical natural language processing, however, its development has been limited by well-annotated datasets and interpretability. To solve this, researchers have considered combining domain knowledge (such as biomedical knowledge graph) with biomedical data, which has become a promising means of introducing more information into biomedical datasets and following evidence-based medicine. This paper comprehensively reviews more than 150 recent literature studies on incorporating domain knowledge into deep learning models to facilitate typical biomedical text analysis tasks, including information extraction, text classification, and text generation. We eventually discuss various challenges and future directions.

Authors

  • Linkun Cai
    College of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Jia Li
    Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan Tsuihang New District, Guangdong, 528400, PR China; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, PR China; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China.
  • Han Lv
    Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wenjuan Liu
    College of Materials Science and Engineering , Nanjing Tech University , Nanjing , Jiangsu 211816 , China.
  • Haijun Niu
    School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Zhenchang Wang
    School of Biological Science and Medical Engineering, Beihang University, Beijing, China.