An efficient deep learning approach to identify dynamics in in vitro neural networks.
Journal:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Published Date:
Jul 1, 2023
Abstract
Understanding and discriminating the spatiotemporal patterns of activity generated by in vitro and in vivo neuronal networks is a fundamental task in neuroscience and neuroengineering. The state-of-the-art algorithms to describe the neuronal activity mostly rely on global and local well-established spike and burst-related parameters. However, they are not able to capture slight differences in the activity patterns. In this work, we introduce a deep-learning-based algorithm to automatically infer the dynamics exhibited by different neuronal populations. Specifically, we demonstrate that our algorithm is able to discriminate with high accuracy the dynamics of five different populations of in vitro human-derived neural networks with an increasing inhibitory to excitatory neurons ratio.