Automated Segmentation of Sacral Chordoma and Surrounding Muscles Using Deep Learning Ensemble.

Journal: International journal of radiation oncology, biology, physics
Published Date: Jul 13, 2023

Abstract

PURPOSE: The manual segmentation of organ structures in radiation oncology treatment planning is a time-consuming and highly skilled task, particularly when treating rare tumors like sacral chordomas. This study evaluates the performance of automated deep learning (DL) models in accurately segmenting the gross tumor volume (GTV) and surrounding muscle structures of sacral chordomas.

Authors

  • Leonard Boussioux
    Operations Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Yu Ma
    Department of Electronic Engineering, Fudan University, Shanghai, China.
  • Nancy Knight Thomas
    Operations Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts; Sloan School of Management, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  • Dimitris Bertsimas
    Dimitris Bertsimas, Jack Dunn, Colin Pawlowski, John Silberholz, Alexander Weinstein, and Ying Daisy Zhuo, Massachusetts Institute of Technology, Cambridge; Eddy Chen, Massachusetts General Hospital Cancer Center; Harvard Medical School; Aymen A. Elfiky, Dana-Farber Cancer Institute; Brigham and Women's Hospital; Harvard Medical School, Boston, MA.
  • Nadya Shusharina
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, United States; Harvard Medical School, Boston, United States.
  • Jennifer Pursley
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
  • Yen-Lin Chen
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
  • Jack Qian
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
  • Thomas Bortfeld
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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