A novel method to identify pre-microRNA in various species knowledge base on various species.

Journal: Journal of biomedical semantics
Published Date: Sep 20, 2017

Abstract

BACKGROUND: More than 1/3 of human genes are regulated by microRNAs. The identification of microRNA (miRNA) is the precondition of discovering the regulatory mechanism of miRNA and developing the cure for genetic diseases. The traditional identification method is biological experiment, but it has the defects of long period, high cost, and missing the miRNAs that but also many other algorithms only exist in a specific period or low expression level. Therefore, to overcome these defects, machine learning method is applied to identify miRNAs.

Authors

  • Tianyi Zhao
    Department of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
  • Ningyi Zhang
    Department of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
  • Ying Zhang
    Department of Nephrology, Nanchong Central Hospital Affiliated to North Sichuan Medical College, Nanchong, China.
  • Jun Ren
    School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
  • Peigang Xu
    Department of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
  • Zhiyan Liu
    Department of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
  • Liang Cheng
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150001, China. liangcheng@hrbmu.edu.cn.
  • Yang Hu
    Kweichow Moutai Co., Ltd, Renhuai, Guizhou 564501, China.

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