Deep Learning Classification of Angle Closure based on Anterior Segment OCT.

Journal: Ophthalmology. Glaucoma
PMID:

Abstract

PURPOSE: To assess the performance and generalizability of a convolutional neural network (CNN) model for objective and high-throughput identification of primary angle-closure disease (PACD) as well as PACD stage differentiation on anterior segment swept-source OCT (AS-OCT).

Authors

  • Jing Shan
    Harvard-MIT Division of Health Sciences and Technology, MIT, E25-518, 77 Massachusetts Ave, Cambridge, MA 02139, United States. Electronic address: js8686@mit.edu.
  • Zhixi Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
  • Ping Ma
    Department of Statistics, University of Georgia, Athens, GA 30602, USA.
  • Tin A Tun
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Sean Yonamine
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California.
  • Yangyan Wu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  • Mani Baskaran
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
  • Monisha E Nongpiur
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Dake Chen
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California.
  • Tin Aung
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
  • Shuning Li
    Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China.
  • Mingguang He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; Centre for Eye Research Australia; Departments of Ophthalmology and Surgery, University of Melbourne, Melbourne, Australia. Electronic address: mingguang.he@unimelb.edu.au.
  • Yangfan Yang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  • Ying Han
    Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.