Reproducibility analysis of automated deep learning based localisation of mandibular canals on a temporal CBCT dataset.

Journal: Scientific reports
PMID:

Abstract

Preoperative radiological identification of mandibular canals is essential for maxillofacial surgery. This study demonstrates the reproducibility of a deep learning system (DLS) by evaluating its localisation performance on 165 heterogeneous cone beam computed tomography (CBCT) scans from 72 patients in comparison to an experienced radiologist's annotations. We evaluated the performance of the DLS using the symmetric mean curve distance (SMCD), the average symmetric surface distance (ASSD), and the Dice similarity coefficient (DSC). The reproducibility of the SMCD was assessed using the within-subject coefficient of repeatability (RC). Three other experts rated the diagnostic validity twice using a 0-4 Likert scale. The reproducibility of the Likert scoring was assessed using the repeatability measure (RM). The RC of SMCD was 0.969 mm, the median (interquartile range) SMCD and ASSD were 0.643 (0.186) mm and 0.351 (0.135) mm, respectively, and the mean (standard deviation) DSC was 0.548 (0.138). The DLS performance was most affected by postoperative changes. The RM of the Likert scoring was 0.923 for the radiologist and 0.877 for the DLS. The mean (standard deviation) Likert score was 3.94 (0.27) for the radiologist and 3.84 (0.65) for the DLS. The DLS demonstrated proficient qualitative and quantitative reproducibility, temporal generalisability, and clinical validity.

Authors

  • Jorma Järnstedt
    Medical Imaging Centre, Department of Radiology Tampere University Hospital, Teiskontie 35, 33520, Tampere, Finland.
  • Jaakko Sahlsten
    Dept. of Computer Science, Aalto University School of Science, Espoo, 00076, Finland.
  • Joel Jaskari
    Dept. of Computer Science, Aalto University School of Science, Espoo, 00076, Finland.
  • Kimmo Kaski
    Dept. of Computer Science, Aalto University School of Science, Espoo, 00076, Finland. kimmo.kaski@aalto.fi.
  • Helena Mehtonen
    Medical Imaging Centre, Department of Radiology Tampere University Hospital, Teiskontie 35, 33520, Tampere, Finland.
  • Ari Hietanen
    Planmeca Oy, Asentajankatu 6, 00880, Helsinki, Finland.
  • Osku Sundqvist
    Planmeca Oy, Asentajankatu 6, 00880, Helsinki, Finland.
  • Vesa Varjonen
    Planmeca Oy, Asentajankatu 6, 00880, Helsinki, Finland.
  • Vesa Mattila
    Planmeca Oy, Asentajankatu 6, 00880, Helsinki, Finland.
  • Sangsom Prapayasatok
    Division of Oral and Maxillofacial Radiology, Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
  • Sakarat Nalampang
    Division of Oral and Maxillofacial Radiology, Faculty of Dentistry, Chiang Mai University, Suthep Rd., T. Suthep, A. Muang, Chiang Mai, Thailand.