Opportunities and Challenges of Synthetic Data Generation in Oncology.

Journal: JCO clinical cancer informatics
Published Date:

Abstract

Widespread interest in artificial intelligence (AI) in health care has focused mainly on deductive systems that analyze available real-world data to discover patterns not otherwise visible. Generative adversarial network, a new type of inductive AI, has recently evolved to generate high-fidelity virtual synthetic data (SD) trained on relatively limited real-world information. The AI system is fed with a collection of real data, and it learns to generate new augmented data while maintaining the general characteristics of the original data set. The use of SD to enhance clinical research and protect patient privacy has drawn a lot of interest in medicine and in the complex field of oncology. This article summarizes the main characteristics of this innovative technology and critically discusses how it can be used to accelerate data access for secondary purposes, providing an overview of the opportunities and challenges of SD generation for clinical cancer research and health care.

Authors

  • Flavia Jacobs
    Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Saverio D'Amico
    IRCCS Istituto Clinico Humanitas, Milan, Italy.
  • Chiara Benvenuti
    Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Mariangela Gaudio
    Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Giuseppe Saltalamacchia
    IRCCS Istituto Clinico Humanitas, Milan, Italy.
  • Chiara Miggiano
    Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Rita De Sanctis
    Department of Medical Oncology and Hematology, Humanitas Cancer Center and Research Hospital, IRCCS, Rozzano, Milan, Italy.
  • Matteo Giovanni Della Porta
    Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Armando Santoro
    IRCCS Humanitas Research Hospital Medical Oncology Unit, Rozzano, Italy.
  • Alberto Zambelli
    ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.