Ki67 proliferation index in medullary thyroid carcinoma: a comparative study of multiple counting methods and validation of image analysis and deep learning platforms.

Journal: Histopathology
PMID:

Abstract

AIMS: The International Medullary Thyroid Carcinoma Grading System, introduced in 2022, mandates evaluation of the Ki67 proliferation index to assign a histological grade for medullary thyroid carcinoma. However, manual counting remains a tedious and time-consuming task.

Authors

  • Saad Nadeem
    Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, United States of America.
  • Matthew G Hanna
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Computational Pathology and AI Center of Excellence (CPACE), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Kartik Viswanathan
    Department of Pathology, Emory University Hospital Midtown, Atlanta, GA, USA.
  • Joseph Marino
  • Mahsa Ahadi
    Royal North Shore Hospital and Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia.
  • Bayan Alzumaili
    Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Mohamed-Amine Bani
    Medical Pathology and Biology Department, Gustave Roussy Campus Cancer, Villejuif, France.
  • Federico Chiarucci
    Department of Medical and Surgical Sciences (DIMEC), University of Bologna Medical Center, Bologna, Italy.
  • Angela Chou
    Royal North Shore Hospital and Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia.
  • Antonio De Leo
    Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
  • Talia L Fuchs
    Royal North Shore Hospital and Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia.
  • Daniel J Lubin
    Department of Pathology, Emory University Hospital Midtown, Atlanta, GA, USA.
  • Catherine Luxford
    Royal North Shore Hospital and Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia.
  • Kelly Magliocca
    Department of Pathology, Emory University Hospital Midtown, Atlanta, GA, USA.
  • Germán Martinez
    Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Qiuying Shi
    Department of Pathology, Emory University Hospital Midtown, Atlanta, GA, USA.
  • Stan Sidhu
    Royal North Shore Hospital and Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia.
  • Abir Al Ghuzlan
    Medical Pathology and Biology Department, Gustave Roussy Campus Cancer, Villejuif, France.
  • Anthony J Gill
    Royal North Shore Hospital, Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Sydney, Australia.
  • Giovanni Tallini
    Department of Medical and Surgical Sciences (DIMEC), University of Bologna Medical Center, Bologna, Italy.
  • Ronald Ghossein
    Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Bin Xu
    Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.