Only the Best of the Bunch-Sperm Preparation Is Not Just about Numbers.

Journal: Seminars in reproductive medicine
PMID:

Abstract

In this , we present an overview of the current and emerging methods and technologies for optimizing the man and the sperm sample for fertility treatment. We argue that sperms are the secret to success, and that there are many avenues for improving both treatment and basic understanding of their role in outcomes. These outcomes encompass not just whether treatment is successful or not, but the wider intergenerational health of the offspring. We discuss outstanding challenges and opportunities of new technologies such as microfluidics and artificial intelligence, including potential pitfalls and advantages. This article aims to provide a comprehensive overview of the importance of sperm in fertility treatment and suggests future directions for research and innovation.

Authors

  • Meurig T Gallagher
    Centre for Human Reproductive Science, Institute of Metabolism and Systems Research, University of Birmingham and Birmingham Women's Fertility Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B15 2TT, United Kingdom.
  • Ingrida Krasauskaite
    Centre for Human Reproductive Science, Institute of Metabolism and Systems Research, University of Birmingham and Birmingham Women's Fertility Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B15 2TT, United Kingdom.
  • Jackson C Kirkman-Brown
    Centre for Human Reproductive Science, Institute of Metabolism and Systems Research, University of Birmingham and Birmingham Women's Fertility Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B15 2TT, United Kingdom.