Deep Generative Models: The winning key for large and easily accessible ECG datasets?

Journal: Computers in biology and medicine
PMID:

Abstract

Large high-quality datasets are essential for building powerful artificial intelligence (AI) algorithms capable of supporting advancement in cardiac clinical research. However, researchers working with electrocardiogram (ECG) signals struggle to get access and/or to build one. The aim of the present work is to shed light on a potential solution to address the lack of large and easily accessible ECG datasets. Firstly, the main causes of such a lack are identified and examined. Afterward, the potentials and limitations of cardiac data generation via deep generative models (DGMs) are deeply analyzed. These very promising algorithms have been found capable not only of generating large quantities of ECG signals but also of supporting data anonymization processes, to simplify data sharing while respecting patients' privacy. Their application could help research progress and cooperation in the name of open science. However several aspects, such as a standardized synthetic data quality evaluation and algorithm stability, need to be further explored.

Authors

  • Giuliana Monachino
    Department of Innovative Technologies, Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Applied Sciences and Arts of Southern Switzerland, Lugano, Switzerland.
  • Beatrice Zanchi
    Institute of Digital Technologies for Personalized Healthcare - MeDiTech, Department of Innovative Technologies, University of Applied Sciences and Arts of Southern Switzerland, Via la Santa 1, Lugano 6900, Switzerland; Department of Quantitative Biomedicine, University of Zurich, Schmelzbergstrasse 26, Zurich 8091, Switzerland.
  • Luigi Fiorillo
    Department of Innovative Technologies, Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Applied Sciences and Arts of Southern Switzerland, Lugano, Switzerland.
  • Giulio Conte
    Division of Cardiology, Fondazione Cardiocentro Ticino, Via Tesserete 48, Lugano 6900, Switzerland; Centre for Computational Medicine in Cardiology, Faculty of Informatics, Università della Svizzera Italiana, Via la Santa 1, Lugano 6900, Switzerland.
  • Angelo Auricchio
    Division of Cardiology, Fondazione Cardiocentro Ticino, Via Tesserete 48, Lugano 6900, Switzerland; Centre for Computational Medicine in Cardiology, Faculty of Informatics, Università della Svizzera Italiana, Via la Santa 1, Lugano 6900, Switzerland.
  • Athina Tzovara
    Institute of Computer Science, University of Bern, Bern, Switzerland.
  • Francesca Dalia Faraci
    Department of Innovative Technologies, Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Applied Sciences and Arts of Southern Switzerland, Lugano, Switzerland.