Does conditioned pain modulation predict the magnitude of placebo effects in patients with neuropathic pain?

Journal: European journal of pain (London, England)
PMID: 29266627

Abstract

BACKGROUND: Conditioned pain modulation (CPM) is a validated measure of the function of endogenous pain inhibitory pathways. Placebo effects reflect top-down inhibitory modulation of pain. CPM and placebo effects are both influenced by expectations, albeit to varying degrees, and are related to neurotransmitter systems such as the endogenous opioid system, and it can be speculated that CPM responses are positively associated with the magnitude of placebo effects. Yet, no studies have tested this.

Authors

  • I Skyt
    Department of Psychology and Behavioural Sciences, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark.
  • K Moslemi
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
  • C Baastrup
    Department of Clinical Biochemistry, Regional Hospital Horsens, Horsens, Denmark.
  • K Grosen
    Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.
  • P Svensson
    Section of Orofacial Pain and Jaw Function, Department of Dentistry, Aarhus University, Aarhus, Denmark.
  • T S Jensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
  • L Vase
    Department of Psychology and Behavioural Sciences, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark.

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