AIMC Topic: Placebo Effect

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Model-informed approach to estimate treatment effect in placebo-controlled clinical trials using an artificial intelligence-based propensity weighting methodology to account for non-specific responses to treatment.

Journal of pharmacokinetics and pharmacodynamics Dec 10, 2024
In randomized, placebo controlled clinical trials (RCT) in major depressive disorders (MDD), treatment response (TR) is estimated by the change from baseline at study-end (EOS) of the scores of clinical scales used for assessing disease severity. Tre...
Humans Models, Statistical Randomized Controlled Trials as Topic Propensity Score Artificial Intelligence Depressive Disorder, Major Treatment Outcome Antidepressive Agents Placebo Effect
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Differential power of placebo across major psychiatric disorders: a preliminary meta-analysis and machine learning study.

Scientific reports Oct 29, 2021
The placebo effect across psychiatric disorders is still not well understood. In the present study, we conducted meta-analyses including meta-regression, and machine learning analyses to investigate whether the power of placebo effect depends on the ...
Psychotropic Drugs Placebo Effect Child Clinical Trials as Topic Young Adult Adult Male Middle Aged Case-Control Studies Adolescent Mental Disorders Female Aged Humans Machine Learning
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Cutoff criteria for the placebo response: a cluster and machine learning analysis of placebo analgesia.

Scientific reports Sep 28, 2021
Computations of placebo effects are essential in randomized controlled trials (RCTs) for separating the specific effects of treatments from unspecific effects associated with the therapeutic intervention. Thus, the identification of placebo responder...
Humans Pain Machine Learning Reference Values Young Adult Randomized Controlled Trials as Topic Lidocaine, Prilocaine Drug Combination Healthy Volunteers Female Adult Treatment Outcome Pain Measurement Placebo Effect Male Cluster Analysis Analgesics Placebos
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A Machine Learning Approach to Identifying Placebo Responders in Late-Life Depression Trials.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry Jan 11, 2018
OBJECTIVE: Despite efforts to identify characteristics associated with medication-placebo differences in antidepressant trials, few consistent findings have emerged to guide participant selection in drug development settings and differential therapeu...
Humans Machine Learning Citalopram Male Female Antidepressive Agents, Second-Generation Single-Blind Method Depression Aged Placebo Effect Treatment Outcome Late Onset Disorders Aged, 80 and over
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Does conditioned pain modulation predict the magnitude of placebo effects in patients with neuropathic pain?

European journal of pain (London, England) Dec 20, 2017
BACKGROUND: Conditioned pain modulation (CPM) is a validated measure of the function of endogenous pain inhibitory pathways. Placebo effects reflect top-down inhibitory modulation of pain. CPM and placebo effects are both influenced by expectations, ...
Placebo Effect Conditioning, Psychological Pain Threshold Middle Aged Aged Humans Pain Measurement Lidocaine Adult Female Pressure Male Neuralgia
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Predicting Placebo Responses Using EEG and Deep Convolutional Neural Networks: Correlations with Clinical Data Across Three Independent Datasets.

Neuroinformatics May 19, 2025
Identifying likely placebo responders can help design more efficient clinical trials by stratifying participants, reducing sample size requirements, and enhancing the detection of true drug effects. In response to this need, we developed a deep convo...
Neural Networks, Computer Female Adult Humans Convolutional Neural Networks Male Electroencephalography Middle Aged Placebo Effect Depressive Disorder, Major
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Comparison of Different Machine Learning Methodologies for Predicting the Non-Specific Treatment Response in Placebo Controlled Major Depressive Disorder Clinical Trials.

Clinical and translational science Jan 1, 2025
Placebo effect represents a serious confounder for the assessment of treatment effect to the extent that it has become increasingly difficult to develop antidepressant medications appropriate for outperforming placebo. Treatment effect in randomized,...
Placebos Depressive Disorder, Major Treatment Outcome Randomized Controlled Trials as Topic Predictive Value of Tests Antidepressive Agents Placebo Effect Humans Neural Networks, Computer Machine Learning
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