Do all sedatives promote biological sleep electroencephalogram patterns? A machine learning framework to identify biological sleep promoting sedatives using electroencephalogram.

Journal: PloS one
PMID: 38954679

Abstract

BACKGROUND: Sedatives are commonly used to promote sleep in intensive care unit patients. However, it is not clear whether sedation-induced states are similar to the biological sleep. We explored if sedative-induced states resemble biological sleep using multichannel electroencephalogram (EEG) recordings.

Authors

  • Sowmya M Ramaswamy
    Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: s.muchukunte.ramaswamy@umcg.nl.
  • Merel H Kuizenga
    Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Maud A S Weerink
    Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Hugo E M Vereecke
    Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Anaesthesiology and Reanimation, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium.
  • Sunil B Nagaraj
    1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.2Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.3Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.4Department of Electronics, Informatics and Bioengineering, Politecnico di Milano, Milan, Italy.
  • Michel M R F Struys
    Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

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