Machine Learning Tools to Assist the Synthesis of Antibacterial Carbon Dots.

Journal: International journal of nanomedicine
PMID: 38855729

Abstract

INTRODUCTION: The emergence and rapid spread of multidrug-resistant bacteria (MRB) caused by the excessive use of antibiotics and the development of biofilms have been a growing threat to global public health. Nanoparticles as substitutes for antibiotics were proven to possess substantial abilities for tackling MRB infections via new antimicrobial mechanisms. Particularly, carbon dots (CDs) with unique (bio)physicochemical characteristics have been receiving considerable attention in combating MRB by damaging the bacterial wall, binding to DNA or enzymes, inducing hyperthermia locally, or forming reactive oxygen species.

Authors

  • Zirui Bian
    Department of Bone, Huangdao District Central Hospital, Qingdao, People's Republic of China.
  • Tianzhe Bao
  • Xuequan Sun
    Weifang Eye Institute, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, People's Republic of China.
  • Ning Wang
    Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China.
  • Qian Mu
    Department of Biomaterials, LongScience Biological (Qingdao) Co, LTD, Qingdao, People's Republic of China.
  • Ting Jiang
    School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China.
  • Zhongxiang Yu
    Heart Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao University, Qingdao, People's Republic of China.
  • Junhang Ding
    Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, People's Republic of China.
  • Ting Wang
    CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
  • Qihui Zhou
    Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, People's Republic of China.

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