Hierarchical Label Distribution Learning for Disease Prediction.

Journal: Studies in health technology and informatics
Published Date:

Abstract

The prediction of disease can facilitate early intervention, comprehensive diagnosis and treatment, thereby benefiting healthcare and reducing medical costs. While single class and multi-class learning methods have been applied for disease prediction, they are inadequate in distinguishing between primary and secondary diagnoses, which is crucial for treatments. In this paper, label distribution is suggested to describe the diagnosis, which assigns the description degree to quantify the diagnosis. Additionally, a novel hierarchical label distribution learning (HLDL) model is proposed to make fine-grained predictions based on the hierarchical classification of diseases, taking into account the relationship among diseases. The experimental results on real-world datasets demonstrate that the HLDL model outperforms the baselines with statistical significance.

Authors

  • Yi Ren
    Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, P. R. China.
  • Jing Xia
    Institute of Parasitic Disease Control, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China. xiaj0608@163.com.
  • Ziyi Yu
    Research Center for Healthcare Data Science, Zhejiang Laboratory, Hangzhou, China.
  • Zhenchuan Zhang
    Research Center for Healthcare Data Science, Zhejiang Laboratory, Hangzhou, China.
  • Tianshu Zhou
    Engineering Research Center of EMR and Intelligent Expert System, Ministry of Education, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou Zhejiang Province, China.
  • Yu Tian
    Key Laboratory of Development and Maternal and Child Diseases of Sichuan Province, Department of Pediatrics, Sichuan University, Chengdu, China.
  • Jingsong Li
    Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, China.