Towards an Explainable AI Platform to Study Interruptions in Cancer Radiation Therapy.

Journal: Studies in health technology and informatics
Published Date: Jan 25, 2024

Abstract

Radiation therapy interruptions drive cancer treatment failures; they represent an untapped opportunity for improving outcomes and narrowing treatment disparities. This research reports on the early development of the X-CART platform, which uses explainable AI to model cancer treatment outcome metrics based on high-dimensional associations with our local social determinants of health dataset to identify and explain causal pathways linking social disadvantage with increased radiation therapy interruptions.

Authors

  • Arash Shaban-Nejad
    UTHSC-ORNL Center for Biomedical Informatics and Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Nariman Ammar
    Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center - Oak-Ridge National Laboratory (UTHSC-ORNL), Center for Biomedical Informatics, Memphis, Tennessee, USA.
  • Fekede Kumsa
    Center for Biomedical Informatics, Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Soheil Hashtarkhani
    University of Tennessee Health Science Center - Oak-Ridge National Lab (UTHSC-ORNL) Center for Biomedical Informatics, Department of Pediatrics, College of Medicine, Memphis, Tennessee, USA.
  • Brianna White
    Center for Biomedical Informatics, Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Lokesh K Chinthala
    Center for Biomedical Informatics-Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, 38103, USA.
  • Chase A Owens
    University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Neil Hayes
    Division of Med Hematology, Department of Medicine, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee, USA.
  • David L Schwartz
    Departments of Radiation Oncology & Preventive Medicine University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee, USA.

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