Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates))
PMID:

Abstract

INTRODUCTION: Within the scope of the project, this study aimed to find novel inhibitors by combining computational methods. In order to design inhibitors, it was aimed to produce molecules similar to the RdRp inhibitor drug Favipiravir by using the deep learning method.

Authors

  • Ersin Güner
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Biruni University, 34010 Topkapı, İstanbul, Turkey.
  • Özgür Özkan
    Teknokent Arı, Pinticks Software Company, Istanbul Technical University, Reşitpaşa Mah. Katar Street, No:4/B204 Sarıyer, İstanbul, Turkey.
  • Gözde Yalcin-Ozkat
    Bioengineering Department, Faculty of Engineering and Architecture, Recep Tayyip Erdogan University, 53100 Rize, Turkey.
  • Süreyya Ölgen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Biruni University, 34010 Topkapı, İstanbul, Turkey.