ECG-only explainable deep learning algorithm predicts the risk for malignant ventricular arrhythmia in phospholamban cardiomyopathy.

Journal: Heart rhythm
PMID:

Abstract

BACKGROUND: Phospholamban (PLN) p.(Arg14del) variant carriers are at risk for development of malignant ventricular arrhythmia (MVA). Accurate risk stratification allows timely implantation of intracardiac defibrillators and is currently performed with a multimodality prediction model.

Authors

  • Rutger R van de Leur
    Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
  • Remco de Brouwer
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
  • Hidde Bleijendaal
    Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam, the Netherlands.
  • Tom E Verstraelen
    Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
  • Belend Mahmoud
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
  • Ana Perez-Matos
    Department of Cardiology, St Antonius Hospital, Sneek, The Netherlands.
  • Cathelijne Dickhoff
    Department of Cardiology, Dijklander Hospital, Hoorn, The Netherlands.
  • Bas A Schoonderwoerd
    Department of Cardiology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.
  • Tjeerd Germans
    Department of Cardiology, Noordwest Hospital Group, Alkmaar, The Netherlands.
  • Arjan Houweling
    Department of Human Genetics, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Paul A van der Zwaag
    Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
  • Moniek G P J Cox
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
  • J Peter van Tintelen
    European Reference Network for Rare, Low-Prevalence, or Complex Diseases of the Heart (ERN GUARD-Heart); Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Anneline S J M Te Riele
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Maarten P van den Berg
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
  • Arthur A M Wilde
    European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart (P.D.L., A.A.M.W.).
  • Pieter A Doevendans
    Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
  • Rudolf A de Boer
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands; Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • RenĂ© van Es
    Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.