Multicancer screening test based on the detection of circulating non haematological proliferating atypical cells.

Journal: Molecular cancer
Published Date: Feb 13, 2024

Abstract

BACKGROUND: the problem in early diagnosis of sporadic cancer is understanding the individual's risk to develop disease. In response to this need, global scientific research is focusing on developing predictive models based on non-invasive screening tests. A tentative solution to the problem may be a cancer screening blood-based test able to discover those cell requirements triggering subclinical and clinical onset latency, at the stage when the cell disorder, i.e. atypical epithelial hyperplasia, is still in a subclinical stage of proliferative dysregulation.

Authors

  • Natalia Malara
    Department of Health Sciences, University Magna Graecia, Catanzaro, IT, Italy. nataliamalara@unicz.it.
  • Maria Laura Coluccio
    Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, IT, Italy.
  • Fabiana Grillo
    Department of Chemistry, University of Leicester, Leicester, UK.
  • Teresa Ferrazzo
    Department of Health Sciences, University Magna Graecia, Catanzaro, IT, Italy.
  • Nastassia C Garo
    Department of Health Sciences, University Magna Graecia, Catanzaro, IT, Italy.
  • Giuseppe Donato
    Department of Health Sciences, University Magna Graecia, Catanzaro, IT, Italy.
  • Annamaria Lavecchia
    Pathology Unit Pugliese Ciaccio Hospital, Catanzaro, IT, Italy.
  • Franco Fulciniti
    Unilabs Pathology, Lugano, CH, Switzerland.
  • Anna Sapino
    Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Turin, Italy.
  • Eliano Cascardi
    Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Turin, Italy.
  • Antonella Pellegrini
    Società Italiana di Citologia (SICi), AO S.Giovanni-Addolorata, President, Roma, IT, Italy.
  • Prassede Foxi
    Cytodiagnostic Pistoia-Pescia Unit, USL Toscana Centro, Pistoia, IT, 51100, Italy.
  • Cesare Furlanello
    a Fondazione Bruno Kessler , Trento , Italy.
  • Giovanni Negri
    Pathology Unit, Central Hospital Bolzano, via Boehler 5, Bolzano, IT, 39100, Italy.
  • Guido Fadda
    Human Pathology Department, Gaetano Barresi University, Messina, IT, Italy.
  • Arrigo Capitanio
    Linköping University Hospital SE , Linköping University, Linköping, Sweden.
  • Salvatore Pullano
    Department of Health Sciences, University Magna Graecia, Catanzaro, IT, Italy.
  • Virginia M Garo
    Department of Health Sciences, University Magna Graecia, Catanzaro, IT, Italy.
  • Francesca Ferrazzo
    Department of Health Sciences, University Magna Graecia, Catanzaro, IT, Italy.
  • Alarice Lowe
    Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
  • Angela Torsello
    UOC Oncology, AO San Giovanni, Roma, IT, Italy.
  • Patrizio Candeloro
    Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, IT, Italy.
  • Francesco Gentile
    Vancouver Prostate Centre, Department of Urologic Sciences, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada.

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