A clinical microscopy dataset to develop a deep learning diagnostic test for urinary tract infection.

Journal: Scientific data
PMID:

Abstract

Urinary tract infection (UTI) is a common disorder. Its diagnosis can be made by microscopic examination of voided urine for markers of infection. This manual technique is technically difficult, time-consuming and prone to inter-observer errors. The application of computer vision to this domain has been slow due to the lack of a clinical image dataset from UTI patients. We present an open dataset containing 300 images and 3,562 manually annotated urinary cells labelled into seven classes of clinically significant cell types. It is an enriched dataset acquired from the unstained and untreated urine of patients with symptomatic UTI using a simple imaging system. We demonstrate that this dataset can be used to train a Patch U-Net, a novel deep learning architecture with a random patch generator to recognise urinary cells. Our hope is, with this dataset, UTI diagnosis will be made possible in nearly all clinical settings by using a simple imaging system which leverages advanced machine learning techniques.

Authors

  • Natasha Liou
    Bladder Infection and Immunity Group (BIIG), UCL Centre for Kidney & Bladder Health, Division of Medicine, University College London, Royal Free Hospital Campus, London, UK.
  • Trina De
    Center for Advanced Systems Understanding (CASUS), Görlitz, Germany.
  • Adrian Urbanski
    Center for Advanced Systems Understanding (CASUS), Görlitz, Germany.
  • Catherine Chieng
    Bladder Infection and Immunity Group (BIIG), UCL Centre for Kidney & Bladder Health, Division of Medicine, University College London, Royal Free Hospital Campus, London, UK.
  • Qingyang Kong
    Bladder Infection and Immunity Group (BIIG), UCL Centre for Kidney & Bladder Health, Division of Medicine, University College London, Royal Free Hospital Campus, London, UK.
  • Anna L David
  • Rajvinder Khasriya
    Bladder Infection and Immunity Group (BIIG), UCL Centre for Kidney & Bladder Health, Division of Medicine, University College London, Royal Free Hospital Campus, London, UK.
  • Artur Yakimovich
    MRC-Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.
  • Harry Horsley
    Bladder Infection and Immunity Group (BIIG), UCL Centre for Kidney & Bladder Health, Division of Medicine, University College London, Royal Free Hospital Campus, London, UK. h.horsley@ucl.ac.uk.