Automating the Detection of IV Fluid Contamination Using Unsupervised Machine Learning.

Journal: Clinical chemistry
Published Date:

Abstract

BACKGROUND: Intravenous (IV) fluid contamination is a common cause of preanalytical error that can delay or misguide treatment decisions, leading to patient harm. Current approaches for detecting contamination rely on delta checks, which require a prior result, or manual technologist intervention, which is inefficient and vulnerable to human error. Supervised machine learning may provide a means to detect contamination, but its implementation is hindered by its reliance on expert-labeled training data. An automated approach that is accurate, reproducible, and practical is needed.

Authors

  • Nicholas C Spies
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Zita Hubler
    Department of Pathology, Washington University in St.Louis School of Medicine, St. Louis, MO, United States.
  • Vahid Azimi
  • Ray Zhang
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Ronald Jackups
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO. rjackups@path.wustl.edu.
  • Ann M Gronowski
    Department of Pathology, Washington University in St.Louis School of Medicine, St. Louis, MO, United States.
  • Christopher W Farnsworth
    Department of Pathology, Washington University in St.Louis School of Medicine, St. Louis, MO, United States.
  • Mark A Zaydman
    Department of Pathology & Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA.