Deceptive learning in histopathology.

Journal: Histopathology
Published Date:

Abstract

AIMS: Deep learning holds immense potential for histopathology, automating tasks that are simple for expert pathologists and revealing novel biology for tasks that were previously considered difficult or impossible to solve by eye alone. However, the extent to which the visual strategies learned by deep learning models in histopathological analysis are trustworthy or not has yet to be systematically analysed. Here, we systematically evaluate deep neural networks (DNNs) trained for histopathological analysis in order to understand if their learned strategies are trustworthy or deceptive.

Authors

  • Sahar Shahamatdar
    Center for Computational Molecular Biology, Brown University, Providence, RI, USA.
  • Daryoush Saeed-Vafa
    Department of Anatomic Pathology, H. Lee Moffitt Cancer and Research Institute, Tampa, FL, USA.
  • Drew Linsley
    Carney Institute for Brain Science, Department of Cognitive, Linguistic & Psychological Sciences, Brown University, Providence, RI, USA.
  • Farah Khalil
    Department of Pathology, Moffitt Cancer Center, Tampa, Florida.
  • Katherine Lovinger
    Department of Molecular Biology, H. Lee Moffitt Cancer and Research Institute, Tampa, FL, USA.
  • Lester Li
    University of Rochester, Rochester, NY, USA.
  • Howard T McLeod
    Intermountain Precision Genomics, St George, UT, USA.
  • Sohini Ramachandran
    Center for Computational Molecular Biology, Brown University, Providence, Rhode Island, United States of America.
  • Thomas Serre
    Carney Institute for Brain Science, Brown University, USA.