Novel 3D-based deep learning for classification of acute exacerbation of idiopathic pulmonary fibrosis using high-resolution CT.

Journal: BMJ open respiratory research
PMID:

Abstract

PURPOSE: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is the primary cause of death in patients with IPF, characterised by diffuse, bilateral ground-glass opacification on high-resolution CT (HRCT). This study proposes a three-dimensional (3D)-based deep learning algorithm for classifying AE-IPF using HRCT images.

Authors

  • Xinmei Huang
    Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
  • Wufei Si
    Purple Mountain Laboratories, Nanjing, Jiangsu, China.
  • Xu Ye
    Hunan Cancer Hospital, Head and Neck Oncology Department, Changsha, China.
  • Yichao Zhao
    Interconnected and Integrated Bioelectronics Lab (I²BL), Department of Electrical and Computer Engineering, UCLA, Los Angeles, CA, USA.
  • Huimin Gu
    Department of Rheumatology, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
  • Mingrui Zhang
    Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
  • Shufei Wu
    Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
  • Yanchen Shi
    Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
  • Xianhua Gui
    Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China mengshucao@nju.edu.cn yonglong11a@163.com xianxian.xian@163.com.
  • Yonglong Xiao
    Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China mengshucao@nju.edu.cn yonglong11a@163.com xianxian.xian@163.com.
  • Mengshu Cao
    Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China mengshucao@nju.edu.cn yonglong11a@163.com xianxian.xian@163.com.