Machine learning-based prediction of cerebral oxygen saturation based on multi-modal cerebral oximetry data.

Journal: Health informatics journal
PMID:

Abstract

This study develops machine learning-based algorithms that facilitate accurate prediction of cerebral oxygen saturation using waveform data in the near-infrared range from a multi-modal oxygen saturation sensor. Data were obtained from 150,000 observations of a popular cerebral oximeter, Masimo O3™ regional oximetry (Co., United States) and a multi-modal cerebral oximeter, Votem (Inc., Korea). Among these observations, 112,500 (75%) and 37,500 (25%) were used for training and test sets, respectively. The dependent variable was the cerebral oxygen saturation value from the Masimo O3™ (0-100%). The independent variables were the time of measurement (0-300,000 ms) and the 16-bit decimal amplitudes values (infrared and red) from Votem (0-65,535). For the right part of the forehead, the root mean square error of the random forest (0.06) was much smaller than those of linear regression (1.22) and the artificial neural network with one, two or three hidden layers (2.58). The result was similar for the left part of forehead, that is, random forest (0.05) vs logistic regression (1.22) and the artificial neural network with one, two or three hidden layers (2.97). Machine learning aids in accurately predicting of cerebral oxygen saturation, employing the data from a multi-modal cerebral oximeter.

Authors

  • Kwang-Sig Lee
    AI Center, Korea University College of Medicine, Seoul, South Korea.
  • Su Jin Kim
    Dae Gon Ryu, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, South Korea.
  • Dong Cheol Kim
    Votem Co., Inc., Chuncheon-si, Korea.
  • Sang-Hyun Park
    Biomedical Research Institute, Korea University College of Medicine, Seoul, Korea.
  • Dong-Hyun Jang
    Department of Emergency Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea.
  • Eung Hwi Kim
    Institute for Healthcare Service Innovation, Korea University College of Medicine, Seoul, Korea.
  • YoungShin Kang
    Institute for Healthcare Service Innovation, Korea University College of Medicine, Seoul, Korea.
  • Sijin Lee
    Department of Emergency Medicine, Korea University Anam Hospital, Seoul, Korea.
  • Sung Woo Lee
    Department of Emergency Medicine, Korea University Anam Hospital, Seoul, Korea.